The Inferior Nasal Turbinate of Sheep as a Model for Studying Post-Interventional Upper Airway Mucosal Remodeling
Haralampos Gouveris1 * and Vasilios Danielides2
Abstract: After using the inferior nasal turbinate (INT) of the sheep to study various surgical interventions, radiofrequency tissue volume reduction (RFTVR) appears to be the less invasive technique currently available to reduce the INT non-osseous volume. The histologic parameters of wound healing such as fibrosis, submucosal interstitial volume, epithelial cell lining necrosis, inflammation and submucosal vascularization provide the measures upon which one should rely in order to compare various surgical (or other) interventions. From a molecular perspective, fibronectin, collagen III, CD68 and matrix metalloproteinase-9 (MMP-9) are candidate control parameters and / or modulators of the wound healing and remodeling processes at the inferior nasal turbinate.
Haralampos Gouveris1 * and Vasilios Danielides2
Abstract: After using the inferior nasal turbinate (INT) of the sheep to study various surgical interventions, radiofrequency tissue volume reduction (RFTVR) appears to be the less invasive technique currently available to reduce the INT non-osseous volume. The histologic parameters of wound healing such as fibrosis, submucosal interstitial volume, epithelial cell lining necrosis, inflammation and submucosal vascularization provide the measures upon which one should rely in order to compare various surgical (or other) interventions. From a molecular perspective, fibronectin, collagen III, CD68 and matrix metalloproteinase-9 (MMP-9) are candidate control parameters and / or modulators of the wound healing and remodeling processes at the inferior nasal turbinate.
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